Levbid (hyoscyamine) is an anticholinergic used to treat irritable bowel syndrome, peptic ulcer disease, hypermotility of the lower urinary tract, and gastrointestinal disorders. Acetylcholine is a … Minor Potential Hazard, Low plausibility. Acta Med Scand 199 Only traces of this drug are found in breast milk. Moderate Potential Hazard, Moderate plausibility. "Harrison's Principles of Internal Medicine. Moban (molindone)." Major Potential Hazard, High plausibility. JAMA 241 (1991): 1658-60, Kanto J "New aspects in the use of atropine." Methenamine is excreted by the kidney and concentrated in the urine. Hyoscyamine belongs to the class of medicines known as anticholinergics/antispasmodics. Hyoscyamine in Irritable Bowel Syndrome (IBS) Irritable Bowel Syndrome or IBS is a persistent disease of the large intestine. Applies to: Renal Dysfunction. N Engl J Med 287 1  Levsin (which also goes by the brand name Anaspaz) is prescribed by a physician to relax the muscles in the bladder and … (1985): 613-4, Berdy GJ, Berdy SS, Odin LS, Hirst LW "Angle closure glaucoma precipitated by aerosolized atropine." Lederle Laboratories, Wayne, NJ. Moderate Potential Hazard, Moderate plausibility. Mevorach D "Adverse effects of atropine sulfate autoinjection." Janssen Pharmaceutica, Titusville, NJ. It is also used to treat other conditions such as bladder and bowel control problems, cramping pain caused by kidney stones and gallstones, and Parkinson's disease. Hyoscyamine may be used in the treatment of a wide variety of gastrointestinal problems including cramps, bladder control issues, and irritable bowel syndrome. BMJ 302 Therapy with anticholinergics should be administered cautiously in patients with tachycardia, congestive heart failure, or coronary artery disease. (1979): 501-2, "Lomotil for diarrhea in children." "Product Information. Applies to: Infectious Diarrhea/Enterocolitis/Gastroenteritis. (1983): 957-9, Forester D "Fatal drug-induced heat stroke." Thorazine (chlorpromazine)." (1972): 390-3, Valentin N, Staffeldt H, Kyst A "Effect of i.v. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Caution is advised even when using agents with mild to moderate anticholinergic activity, particularly in elderly patients. We comply with the HONcode standard for trustworthy health information -, https://www.drugs.com/ppa/hyoscyamine.html, Drug class: anticholinergics/antispasmodics, Hyoscyamine Orally Disintegrating Tablets. (1975): 281-5, Lunde P "Ventricular fibrillation after intravenous atropine for treatment of sinus bradycardia." Am J Cardiol 33 Applies to: Ulcerative Colitis. Zyrtec (cetirizine)." Therapy with atropine-like agents should be administered cautiously to patients with liver disease. Antimuscarinic agents may further aggravate the diarrhea. Follow all directions on your prescription label and read all medication guides or instruction sheets. (1978): 426-30, Brock-Utne JG, Rubin J, Downing JW, Dimopoulos GE, Moshal MG, Naicker M "The administration of metoclopramide with atropine. (1992): 564. Moderate Potential Hazard, Moderate plausibility. Applies to: Hyperthyroidism. Only traces of this drug are found in breast milk. Kidney disease is often only diagnosed at this stage if a routine test for another condition, such as a blood or urine test, detects a possible problem. liver or kidney disease; heart problems; or; breathing problems. Proc Soc Exp Biol Med 139 It is also used to control muscle spasms in the bladder, kidneys, or digestive tract, and to reduce stomach acid. Parke-Davis, Morris Plains, NJ. "Product Information. ESI Lederle Generics, Philadelphia, PA. "Product Information. Antacids may interfere with hyoscyamine, reducing its effectiveness. Talk to your doctor urgently if you experience unexplained diarrhea, eye pain, a fast or irregular heartbeat, or develop a skin rash. Br J Anaesth 53 The half-life of hyoscyamine sulfate is 2 to 3 1/2 hours. In addition to theses, this medicine is considered good for Parkinson’s disease. (1979): 476-90. Premature ventricular depolarization or ventricular tachycardia or fibrillation associated with antimuscarinic drugs is rare. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use hyoscyamine only for the indication prescribed. Applies to: Liver Disease. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. In general, because antiperistaltic agents decrease gastrointestinal motility, they may delay the excretion of infective gastroenteric organisms or toxins and should be used cautiously in patients with any infectious diarrhea, particularly if accompanied by high fever or pus or blood in the stool. (1991): 1403-4, Nahata MC, Clotz MA, Krogg EA "Adverse effects of meperidine, promethazine, and chlorpromazine for sedation in pediatric patients." These drugs should be administered cautiously in patients with gastroesophageal reflux or hiatal hernia associated with reflux esophagitis. Hyoscyamine is used to treat a variety of stomach /intestinal problems such as cramps and irritable bowel syndrome. Marezine (cyclizine)." Major Potential Hazard, Moderate plausibility. References. Dimetane (brompheniramine)." JACEP 7 Hyoscyamine is used to treat many different stomach and intestinal disorders, including peptic ulcer and irritable bowel syndrome. Acta Anaesthesiol Scand 28 Sandoz Pharmaceuticals Corporation, East Hanover, NJ. It is also used to control muscle spasms in the bladder, kidneys, or digestive tract, and to reduce stomach acid. (1973): 348-50, Lee BS "Possibility of hyperpyrexia with antipsychotic and anticholinergic drugs." Major Potential Hazard, Moderate plausibility. Antimuscarinic agents block vagal inhibition of the SA nodal pacemaker. Anaesthesia 31 Am J Gastroenterol 70 This alkaloid is also useful for fighting certain Parkinson’s disease symptoms. Do not give this medicine to a child without medical advice. Talk to your doctor about decreasing your dosage if you experience an excessively dry mouth. Premature ventricular depolarization or ventricular tachycardia or fibrillation associated with anticholinergics is rare. Compazine (prochlorperazine)." This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Merck & Co, Inc, West Point, PA. "Product Information. It is also used to control muscle spasms in the bladder, kidneys, or digestive tract, and to reduce stomach acid. There are 19 disease interactions with hyoscyamine: Major Potential Hazard, High plausibility. It blocks the action of acetylcholine at parasympathetic sites in sweat glands, salivary glands, stomach secretions, heart muscle, sinoatrial node, smooth muscle in the gastrointestinal tract, and the central nervous system. Do not give this medicine to a child without medical advice. Kidney disease is most often caused by other conditions that put a strain on the kidneys. The half-life of hyoscyamine sulfate is 2 to 3 1/2 hours. Effects last for six-to-eight hours (immediate release formulations) or twelve hours (extended-release formulations). 14th ed." Applies to: Arrhythmias, Ischemic Heart Disease . Moderate Potential Hazard, Moderate plausibility. J Clin Psychiatry 47 Am J Ophthalmol 99 Thyroid levels should be monitored if usage is prolonged. Applies to: Hypertension. Revision date: June 10, 2020. New York, NY: McGraw-Hill Health Professionals Division View complete list of side effects. (1976): 369-71, Cooper MJ, Abinader EG "Atropine-induced ventricular fibrillation: case report and review of the literature." Therefore, these drugs should be administered cautiously in patients with diarrhea. In general, agents with anticholinergic activity may exacerbate hyperthyroidism. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Hyoscyamine is also used as a drying agent to control excessive salivation, runny nose, or excessive sweating. Major Potential Hazard, High plausibility. Applies to: Gastroesophageal Reflux Disease. Schering Laboratories, Kenilworth, NJ. Tavist (clemastine)." Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Hyoscyamine is sometimes used to reduce tremors and rigid muscles in people with symptoms of Parkinson's disease. Antimuscarinic agents block vagal inhibition of the SA nodal pacemaker. Applies to: Arrhythmias, Ischemic Heart Disease. (1973): 635, Das G, Talmers FN, Weissler AM "New observations on the effects of atropine on the sinoatrial and atrioventricular nodes in man." These drugs should be administered cautiously to patients with ulcerative colitis. Antimuscarinic agents may cause a delay in gastric emptying and possibly antral stasis in patients with gastric ulcer. The half-life of hyoscyamine sulfate is 2 to 3 1/2 hours. "Product Information. How it works. diazepam, oxybutynin, dicyclomine, lidocaine, Valium, fentanyl, Amitiza, simethicone, Metamucil, Bentyl. Artane (trihexyphenidyl)." Applies to: Fever. Note that this list is not all-inclusive and includes only common medications that may interact with hyoscyamine. Ann Pharmacother 26 "Product Information. Applies to: Asthma. Section II: Anticholinergic drugs." Scopolamine, another useful alkaloid drug, can be produced by the recrystallization of Hyoscyamine. Relieves spasms or cramping and controls excessive bronchial, pharyngeal, stomach, and tracheal secretions. Pfizer US Pharmaceuticals, New York, NY. J Pediatr Gastroenterol Nutr 9 (1971): 13-34. Muscarinic receptor antagonists reduce bronchial secretions, which can result in decreased fluidity and increased thickening of secretions. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Atropine-like agents may increase the risk of hyperthermia in patients with fever by producing anhidrosis. Use the medicine exactly as directed. Anaesthesia 31 Klinge E, Mannisto P, Mantyla R, Lamminsivu U, Ottoila P "Pharmacokinetics of methenamine in healthy volunteers." Anaesthesia 34 Anticholinergics work by blocking the action of the neurotransmitter acetylcholine in the brain and at nerves throughout the body. Agents with anticholinergic activity can exacerbate many of the manifestations of autonomic neuropathy, including tachycardia, anhidrosis, bladder atony, obstipation, dry mouth and eyes, cycloplegia and blurring of vision, and sexual impotence in males. Antimuscarinic agents decrease gastric motility and relax the lower esophageal sphincter which promotes gastric retention and can aggravate reflux. Moderately clinically significant. J Antimicrob Chemother 9 (1982): 209-16 Australian Drug Evaluation Committee "Adverse effects of drugs … (1977): 77-9, Blamoutier J "Comparative trial of two antihistamines, mequitazine and brompheniramine." Atropine-like agents undergo significant hepatic metabolism. Hyoscyamine sulfate Injection, USP inhibits specifically the actions of acetylcholine on structures innervated by postganglionic cholinergic nerves and on smooth muscles that respond to acetylcholine but lack cholinergic innervation. Last updated on Jun 10, 2020. Periactin (cyproheptadine)." An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Am J Cardiol 36 Applies to: Diarrhea. (1974): 327-32, Lazzari JO, Benchuga EG, Elizari MV, Rosenbaum MB "Ventricular fibrillation after intravenous atropine in a patient with atrioventricular block." (1974): 661-4, Goldstein JH "Effects of drugs on cornea, conjunctiva, and lids." Applies to: Autonomic Neuropathy. However, ipratropium does not produce these effects and can be used safely in treating asthma. May not be suitable for some people including those with heart or lung disease, liver or kidney disease, myasthenia gravis, prostate or thyroid problems, ulcerative colitis or an intestinal obstruction. Hyoscyamine may also be used to treat rhinitis. A drug interaction effect on the gastro-oesophageal sphincter in man." Drowsiness and dry mouth are common side effects. Int J Clin Pharmacol Ther Toxicol 21 (1992): 880, Shutt LE, Bowes JB "Atropine and hyoscine." Hyoscyamine is used to treat a variety of stomach/intestinal problems such as cramps and irritable bowel syndrome. Medicines that interact with hyoscyamine may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with hyoscyamine. Ann Ophthalmol 11 Also, anticholinergic drugs may aggravate partial obstructive uropathy. Follow all directions on your prescription label and read all medication guides or instruction sheets. Speak to your doctor about how drug interactions should be managed. Common medications that may interact with hyoscyamine include: Avoid drinking alcohol while taking hyoscyamine. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Anticholinergics are contraindicated in patients with obstructive diseases such as achalasia, esophageal stricture or stenosis, pyloroduodenal stenosis, stenosing peptic ulcer, pyloric obstruction, and paralytic ileus. Dysuria may occur and may require catheterization. Med Lett Drugs Ther 17 Can Med Assoc J 128 Hyoscyamine inhibits the action of acetylcholine, the main neurotransmitter of the parasympathetic nervous system. Cogentin (benztropine)." (1975): 104, Marshall WF Jr, Rosenthal P, Merritt RJ "Atropine therapy and paralytic ileus in an infant." Moderate Potential Hazard, Low plausibility. It is by slowing down the natural … Take with food. 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