The principal effect exerted by 2-butoxyethanol is haematotoxicity, with the rat being the most sensitive species. The ingested dose of butylglycol was about 25–30 g giving a blood level of 0.43 g/l upon admission. The applicant's reasons for the proposal were: 2-Butoxyethanol is in Schedule 6, Appendix E and Appendix F of the Poisons Standard as follows: 2-BUTOXYETHANOL and its ACETATES except in preparations containing 10 per cent or less of such substances. Interestingly, these studies found that the dispersant alone was less toxic than the dispersant–oil mixture. The application to amend the current Poisons Standard with respect to 2-butoxyethanol; The advice received from the Joint Advisory Committees on Medicines and Chemicals Scheduling (Joint ACMS-ACCS #19); The Australian Health Ministers' Advisory Council's. NTP No component of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP. phone Australia 13 11 26; New Zealand 0800 764 766) or a doctor, or for at least 15 minutes), S1 (If skin or hair contact occurs, remove contaminated clothing and flush skin and hair with running water). Further, an elevation of tissue hypoxia combined with hematopoietic signaling in the bone marrow leads to the development of hemangiosarcoma [37,38]. Glycol is a chemical compound that is diol containing two hydroxyl groups. 2-Butoxyethanol is readily absorbed via all routes of exposure (inhalation, dermal, ingestion) with low to moderate acute toxicity via oral, dermal and inhalation routes. An acute inhalation of aerosolized dispersant resulted in the following at 1 day postexposure: (1) no significant lung damage or inflammation, (2) a small but significant increase in heart rate and blood pressure, (3) delayed recovery of blood vessels following constrictions, and (4) alteration in olfactory signal transmission, axonal function, and synaptic vesicle fusion. 2-Butoxyethanol is used in many industries. 2-Butoxyethanol was identified as a causal agent in the health problems experienced by cleanup workers after the 1989 Exxon Valdez oil spill. According to the 2016 Annual Report of the American Association of Poison Control Centers, there were 6325 single exposures to ethylene glycol with 32 fatalities. The spectrum of immune alterations detected appeared to be more extensive with 2-ME exposure as opposed to 2-BE exposure. Read more here. ROS are capable of reacting with cellular proteins, lipids and other molecules leading to changes in their structure and subsequent cellular damage. The ecological and human health impacts of the Deepwater Horizon oil blowout may differ from the previous oil spills such as the Exxon Valdez because of the depth at which the oil leak occurred, the large volume of oil released, and the unprecedented volume of dispersant (COREXIT 9500 and 9527) used. 2010. EPA conducted independent studies to determine the hazards of the dispersants including COREXIT 9500A, and the cytotoxicity results in vitro in concentrations above 10 ppm showed that none of the eight dispersants tested displayed significant estrogenic and androgenic activity. Based on limited data from case reports and one laboratory study, similar acute effects, including haemolytic and CNS effects are observed in humans and rats exposed to 2-butoxyethanol, although the effects are observed at much higher exposure concentrations in humans than in rats. Animal experiments have shown that magnesium antagonizes nickel-induced carcinogenesis in the rat kidney, whereas iron tends to enhance it (Kasprzak et al., 1994). Canada completed its assessment of 2-butoxyethanol in 2002 and as a result developed regulations to limit its concentration in a variety of consumer products intended for indoor use: 2-Butoxyethanol Regulations (SOR/2006-347). Although mechanistically important, these results may only be extrapolated to the in vivo situation where the compound under test is not modified by host metabolic processes. It is a colorless liquid with a sweet, ether-like odour. The application proposed the following amendments to the Poisons Standard: Deleted text is shown as red, smaller font, with a strikethrough. However, in vitro studies have investigated the effect of compounds on the direct lysis of erythrocytes and the inhibition of growth of hematopoietic colonies in culture systems. By continuing you agree to the use of cookies. EGME has been reported to affect conditioned avoidance behavior in trained rats, and PGME has been reported to cause central nervous system (CNS) depression. The testicular effects have been observed in mice, rats, rabbits, and dogs, and the hematological effects have been observed in mice, rats, rabbits, cats, dogs, and man. Humans may be less sensitive. It's tough on germs, but it isn't listed by the Environmental Protection Agency as a disinfectant and isn't a substitute for chlorine bleach. Mice were not affected. This group consists of the monoalkyl ethers of ethylene glycol (EG), including EG butyl ether (butylglycol, butyl Cellosolve), EG monomethyl ether (methyl Cellosolve) and EG monoethyl ether (Cellosolve). 2-Butoxyethanol is a useful solvent in a range of applications, including agricultural and domestic products, medicines and cosmetics. It can harm the eyes, skin, kidneys, and blood. Uses advised against Food, drug, pesticide or biocidal product use. Breast cancer cells have been shown to display 5–15 times more transferrin receptors than normal breast tissue cells. Benefits: 2-Butoxyethanol is a useful solvent in a range of applications. No public submissions were received before the first closing date in response to an invitation published on 12 April 2018 under regulation 42ZCZK of the Regulations. It is prepared by reacting 2-butoxyethanol with acetic acid, acetic acid anhydride, or acetic acid chloride. Beware: Your Green Cleaning Product May Be Toxic. Similar to ethylene glycol, diethylene glycol is used in antifreeze, brake fluids, and deicing solutions. In humans, increased body stores of iron have been shown to increase the risk of several estrogen-induced cancers (e.g., breast cancer; Liehr and Jones [2001]). 2-butoxyethanol is not considered to be a skin sensitiser. Butoxyethanol, also known as 2-Butoxyethanol, is a widely used solvent. Intraperitoneal administration of ferric iron-ATP (FeATP) has been studied in an animal model. Linda A. Malley, in Encyclopedia of Toxicology (Second Edition), 2005. Identification Product Name 2-Butoxyethanol Cat No. Butyl cellosolve, butyl oxitol and ethylene glycol butyl ether are a few of the chemicals you may see listed on varnishes, strippers, herbicides, household cleaners and even cosmetics. The National Institute for Occupational Safety and Health evaluated the acute effects of inhalation of dispersant in rats on the respiratory, cardiovascular, and nervous systems as well as the immune effects of dermal exposure. The PSC also noted that other alkyl ethers of demonstrated haematological effects which increased with chain lengths. Only for use in topical medicines for dermal application and not to be included in medicines intended for use in the eye. In August 1998, the NDPSC noted that 2-butoxyethanol is currently included in Schedule 6 (in preparations containing > 10%) through the class entry of ethylene glycol monoalkyl and their acetates. In addition, there is considerable variation in the susceptibility of cells from different mouse strains to the nitroso metabolite. The potential for human toxicity has not yet been established. It is estimated that 16.5 million gallons of oil was chemically dispersed during the Deepwater Horizon spill. D. Jacobsen, K.E. 2-Butoxyethanol Petroleum Uses This product is an essential component of fracturing fluids, drilling stabilizers, and oil slick dispersants for water-based and oil-based hydraulic fracturing. S. Othumpangat, V. Castranova, in Encyclopedia of Toxicology (Third Edition), 2014. The National Industrial Chemicals Notification and Assessment Scheme (NICNAS) Inventory Multi-tiered Assessment and Prioritisation (IMAP) programme had reviewed a number of chemicals in this class and recommended that separate entries be created for selected chemicals (see Human health tier II assessment for Ethanol, 2-butoxy acetate). Butoxyethanol is an excipient ingredient in 5 products on the Australian Register of Therapeutic Goods (ARTG). Two are medicines (antiseptic handrubs), containing butoxyethanol at a concentration of 0.1%) and 3 are medical devices (disinfectants) that contain butoxyethanol at concentrations of 0.25-9 % w/w. 2-Butoxyethanol is also used in medicines and medical devices currently registered on the ARTG. However, propylene glycol ethers do not cause the testicular or hematological effects and are not teratogenic, although fetotoxicity has been reported in some studies at concentrations that also produced maternal toxicity. At this time, 2-butoxyethanol was captured by the generic entry in Schedule 6 for ethylene glycol monoalkyl ethers and their acetates except those containing 10% or less. Because this product can work as a surfactant, it is able to absorbs at the oil-water interface of the fracture. McMartin, in Human Toxicology, 1996. Chlorine Dioxide (CLO2) “The Ideal Disinfectant” is highly effective against Viruses, Bacteria, Mold, Fungi, Algae, Protozoa, and Biofilm. Additional toxicities include neurotoxicity (loss of coordination, sluggishness and narcosis) and nephrotoxicity. Many oxidants cause hemolysis by this mechanism (e.g., acetanilide, naphthalene, phenol; Table 22.2). The matters under subsection 52E (1) of the Therapeutic Goods Act 1989 considered relevant by the delegate for the decision include: The delegate considered the following in regards to this interim decision: The pre-meeting scheduling proposal was published on the TGA website on 12 April 2018 at Consultation: Proposed amendments to the Poisons Standard being referred to the June 2018 meetings of the ACCS, ACMS and Joint ACCS/ACMS. A review of results for more than 500 chemicals tested in rodents in NTP 2 year bioassays indicated that an increased incidence of cardiac thrombosis, which could be fatal if the left atrium was affected, was associated with 9 different compounds comprising 2-butoxyethanol, bis(2-chloroethoxy)methane, isobutene, 3,3′-dimethoxybenzidine dihydrochloride, C.I. This global health concern appears to be escalating as new information is coming out on a daily basis. : AC403390000, AC403395000 CAS-No 111-76-2 Synonyms Butyl cellosolve; Ethylene glycol monobutyl ether, Butyl glycol Recommended Use Laboratory chemicals. Blood and bone marrow toxicity may be a result of an off-target inhibition (e.g., kinases and/or growth factors) leading to decreased bone marrow response or a result of peripheral effects leading to destruction of blood cells. 2-butoxyethanol has low to moderate acute toxicity via oral, dermal and inhalation routes, and severe skin and eye irritancy. Two are medicines (antiseptic handrubs), containing butoxyethanol at a concentration of 0.1%) and 3 are medical devices (disinfectants) that contain butoxyethanol at concentrations of 0.25-9 % w/w. The first aid instructions in the Poisons Standard (Appendix E, Standard Statements A, E2 and S1) for 2-butoxyethanol are inconsistent with the eye and skin irritation. Like other members of its family, it’s derived from crude oil, and can significantly harm your animal companion if ingested or inhaled over long periods. Other less frequently encountered glycols include diethylene glycol, propylene glycol, ethylene glycol monobutyl ether (EGBE), and ethylene glycol monomethyl ether (EGME). 2-Butoxyethanol is not classified with respect to carcinogenicity. In COREXIT 9500 the toxic 2-butoxyethanol was replaced with light petroleum distillate. U.S. Environmental Protection Agency. Animal studies have shown significant effects from some of the glycol ethers, notably hemolytic anemia for butylglycol [71] and teratogenicity for methylglycol and ethylglycol [72]. There was an indication of ethanol inhibition of butylglycol metabolism and of an effect of hemodialysis in this patient. 2-butoxyethanol 111-76-2 OSHA No component of this product present at levels greater than or equal to 0.1% is on OSHA’s list of regulated carcinogens. Inhalation exposure to high concentrations of compounds in the ethylene series can cause lethality. While Force of Nature is an EPA-registered disinfectant in the United States, it is not yet registered as a disinfectant in Canada. Yes. Despite evidence in the NICNAS IMAP report which suggested that concentrations higher than 10 per cent can be used safely for some alkoxyethanols, the ACCS did not recommend raising the current 10 per cent cut-off. Butoxyethanol is not permitted for use in aerosol dispenser (sprays). Few human cases have been published and the treatment is probably similar within this group. 2. The committee considered that the acute toxicological profile, particularly in regard to eye and skin irritancy and the ready absorption by the dermal route, indicated that Schedule 6 remained appropriate for this compound and did not support the proposal for rescheduling. The advice from the ACCS was that the toxicity profile of 2-butoxyethanol is consistent with Schedule 6 criteria and that it was adequately captured by the current generic entry for ethylene glycol monoalkyl ethers and their acetates, and the specific 2-butoxyethanol and its acetates Schedule 6 entry. Builds no resistance with continuous use. Experiments on hamsters have shown that estrogen treatment increased the non-heme iron in liver of both high and low iron treatment groups and in kidney of the hamsters on the low-iron diet. In November 1984, the Poisons Schedule (Standing) Committee (PSC) considered the scheduling of ethylene glycol monoalkyl ethers and their acetates. Despite numerous cellular defense mechanisms such as antioxidant enzymes and low molecular weight antioxidants such as GSH, hemolysis may result if these mechanisms are overwhelmed in red blood cells. The delegate's decision was based on the fact that hexyloxyethanol's toxicity profile was different from the chemical class ethylene glycol monoalkyl ethers. Acetic acid or white vinegar is a great disinfectant. This bathroom cleaner contains up to 10 percent of a toxic solvent called 2-butoxyethanol. COREXIT manufacturers claim that COREXIT 9500 is a simple blend of six well-established, safe ingredients that biodegrade, do not bioaccumulate, and do not contain carcinogens or reproductive toxins, and that all the ingredients have been extensively studied for many years and have been determined to be safe and effective by the US Environmental Protection Agency (EPA). 100% Degradable. Oil dispersants are detergent-like surfactants comprised of anionic and nonionic molecules dissolved or suspended in solvent that render both hydrophilic and hydrophobic properties to the dispersant. The metabolic acidosis was due to the butylglycol metabolite, butoxy acetic acid, and to lactate. Overexposure can cause anemia, intoxication and irritation of the eyes and nose. 2-Butoxyethanol acetate in the environment also comes from some industrial activities. Used in industry for degreasing and detergent applications.2-n-Butoxyethanol is used in the industry for degreasing and detergent applications. Studies suggest that rats are more susceptible to haemolytic effects than humans and that rats exposed to 2-butoxyethanol develop tolerance and show reduced haemolytic effects over time, or on future exposure. The dispersant COREXIT 9527 contains propylene glycol, 2-butoxyethanol, and dioctyl sodium sulfosuccinate. The delegate also decided to create new Appendices E, F and I entries specifically for hexyloxyethanol. Continued treatment with 2-butoxyethanol resulted in hemosiderin deposition in the liver, indicating that the liver tumors were mediated by oxidative iron catalyzed stress and Kupffer cell activation (Park et al., 2002). In August 1995, the NDPSC considered a proposal to either exempt 2-butoxyethanol from scheduling or create a separate entry for 2-butoxyethanol in Schedule 5. The level of exposure depends upon the dose, duration, and work being done. 2-Butoxyethanol has severe skin and eye irritancy consistent with Schedule 6 factors of the SPF. 2-Butoxyethanol is not considered to be genotoxic. Until this is complete we can not claim that it is a disinfectant in Canada. Estrogen administration increases iron accumulation in hamsters and facilitates iron uptake by cells in culture. In experimental studies, 2-butoxyethanol increased liver tumors in B6C3F1mice after chronic exposure. For example, laboratory animals treated with EGME were observed to develop testicular atrophy, bone marrow hypoplasia (pancytopenia) with secondary effects on red blood cell and white blood cell indices. Skin and eye irritation consistent with Schedule 6. Continue flushing until advised to stop by a Poisons Information Centre (e.g. 111-76-2. In domestic cleaners, the formulations generally fall below 10%, but higher concentrations are found in some products such as oven cleaners and floor strippers. A significant dose- and time-dependent increase in lipid peroxidation products was found in red blood cells treated with microcystin-LR when compared with untreated controls (Sicinska et al., 2006). EGME was teratogenic, embryotoxic, and fetotoxic in pregnant animals. EWG's air pollution tests found that Comet Disinfectant Cleanser Powder emitted 146 different chemicals, including some that have been linked to cancer, … An elevated dietary iron intake enhances the incidence of carcinogen-induced mammary tumors in rats and estrogen-induced kidney tumors in Syrian hamsters. To keep glass germ-free, use a disinfectant first and then wipe it down with Windex Original Glass Cleaner. It may be accidentally ingested, particularly by children as it tastes sweet, or intentionally ingested by adults as an ethanol substitute or to inflict self-harm. 2-Butoxyethanol is used as a solvent in a range of applications. Glycols are associated with severe morbidity and an increased risk of death. It must be packaged separately and has an additional HAZMAT transportation fee. SAFETY DATA SHEET Creation Date 24-Jul-2007 Revision Date 23-Jan-2018 Revision Number 4 1. In November 2013, based on the ACCS advice, the delegate created a separate schedule entry for hexyloxyethanol with a cut-off level to exempt from scheduling for preparations containing 10 per cent of less of hexyloxyethanol. Alterations in the blood and bone marrow cells may also be an anticipated pharmacologic event during preclinical drug development (Meyer et al., 2010). high . Respiratory irritant consistent with Schedule 6. 2-Butoxyethanol is a common ingredient in multi-purpose cleaners and window sprays. Thus, iron-dependent DNA damage has been suggested as one mechanism of action of human arsenic carcinogenesis (Ahmad et al., 2002). Mary B. Nabity, Shashi K. Ramaiah, in Veterinary Toxicology (Second Edition), 2012. 2-Butoxyethanol is not currently used in a proprietary ingredient (PI formulation). In general, the hemolytic effects appear to increase with the size of the alkoxy group. The monoalkyl ethylene glycol ethers have been shown to possess a wide spectrum of biological activity, with some variation in the range of effects and potency among the individual compounds. Among the first studies is that of Exon et al. The Novel Human Corona Virus that originated in Wuhan China now called SARS-CoV-2 the cause of COVID-19 has been declared a pandemic. GUNNAR F. NORDBERG, ... BRUCE A. FOWLER, in Handbook on the Toxicology of Metals (Third Edition), 2007. Rodney R. Dietert, in Endocrine Disruption and Human Health, 2015. Some types of glycol ethers found in cleaning products are 2 Butoxyethanol, a lung irritant and possible carcinogen that may cause liver damage, and 4-t-nonylphenol, an … The morbidity and mortality rate were higher with FeATP, indicating two different interactions (intensity and duration) with the cell plasma membrane (Anghileri et al., 2002). However, exposure to compounds in the propylene series was not lethal to rodents even at nearly saturated concentrations. It is thought that 2-butoxyethanol contributed to the significantly shorter lifespan of Exxon Valdez clean-up workers, which is why Corexit 9527, which also contains the chemical was banned in the United Kingdom. However, there are other forms of leukemia that have weak correlations with exposure to alkylating agents (Bloom and Brandt, 1997). One such compound that has been extensively tested is microcystin-LR, which significantly increases oxidative stress causing lipid peroxidation, changes in membrane fluidity, transformations of cell shape and hemolysis. The authors suggest that iron may also act as a promoter of already initiated hepatocytes in the development of liver cancer in humans (Carthew et al., 1997). Ironically, chemotherapeutic and other toxic agents, particularly alkylating agents, may result in leukemia, which is likely linked to cytogenetic abnormalities, especially with the loss of part or all of a chromosome. acid red 114, C.I. But there are some Windex products that do kill germs, like Windex Disinfectant Multi-Surface Cleaner. Respiratory irritant consistent with Schedule 6 factors of the SPF. Canada only allows this chemical’s use in non-aerosol cleaners up to 6 percent. Glycol ethers as a class are not acutely toxic by the oral route. The frequency of cytogenetic abnormalities in human patients who develop dysplastic syndrome or acute leukemia after treatment with alkylating or other antineoplastic agents ranges from 67 to 95%. Two patients following methyl cellosolve ingestion developed metabolic acidosis and coma [75]. Such bone marrow effects are not uncommon with oncology drugs where bone marrow inhibition may be an acceptable side effect of cancer treatment. The results of in vitro studies indicate that human red blood cells are not as sensitive as rat red blood cells to the haemolytic effects of 2-butoxyethanol and 2-butoxyacetic acid and also that red blood cells are more sensitive to haemolysis by 2-butoxyacetic acid than to haemolysis by 2-butoxyethanol. Members agreed that the relevant matters under Section 52E(1) of the Therapeutic Goods Act 1989 included: (a) risks and benefits of the use of a substance; (b) the purpose for which a substance is to be used and the extent of use; (c) the toxicity of a substance; and (d) the dosage, formulation, labelling, packaging and presentation of a substance. Windex Original Glass Cleaner is not a disinfectant and it will not kill germs. The application proposes to amend the Schedule 6 entry for 2-butoxyethanol in the Poisons Standard to increase the exemption concentration from 10 per cent to 20 per cent. In a study of topical exposure of mice to 2-BE, Singh et al. In February 1985, the PSC reconsidered the November 1984 decision and decided to raise the Schedule 6 ethylene glycol monoalkyl ethers and their acetates exemption cut-off from 5 per cent to 10 per cent. Classic examples of a discrepancy between in vitro and in vivo studies include chloramphenicol-induced myelosuppression and 2-butoxyethanol-induced hemolysis (Turton et al., 2002a, b; Corley et al., 2005). Lipids and other molecules leading to changes in their structure and is butoxyethanol a disinfectant cellular.. Health concern appears to be escalating as new Information is coming out on a daily basis prepared by 2-butoxyethanol... Products as well as the parent glycol ether ₉ OCH ₂ CH ₂ OH ) a..., rust removers, oven and carpet cleaners that have weak correlations with exposure to compounds in United. 2021 Elsevier B.V. or its licensors or contributors, 2 butoxyethanol was applied to the shaved skin of pregnant.... Would be reasonable to treat these poisonings like those with ethylene glycol monoalkyl ethers, sluggishness and )! Cellular proteins, lipids and other molecules leading to changes in their structure and subsequent cellular.! Also maintain the growth of malignant cells, as well as a plant regulator., sodium Hydroxide, 2-butoxyethanol, and relatively nonvolatile liquid that is diol containing two hydroxyl groups uncommon... To 6 percent ethers, such as ammonia, sodium Hydroxide, 2-butoxyethanol is a fact. Review of ethylene glycol, diethylene glycol is ethylene glycol is ethylene glycol, should! Provide and enhance our service and tailor content and ads the treatment is probably similar this. Bloom and Brandt, 1997 ) approximately 20 % 2-butoxyethanol butyl glycol Recommended use Laboratory...., allowing a higher percentage cut off ferrous sulfate for lacquers, varnishes, epoxy resins, dioctyl! Principal effect exerted by 2-butoxyethanol is very widely used solvent the acetates derived from the glycol have... Act as a surfactant in domestic and industrial products butyl ether of ethylene glycol monobutyl ether butyl... Domestic cleaning applications Garg,... BRUCE A. FOWLER, in Encyclopedia Toxicology. Most sensitive species crude oil, and deicing solutions due to the use cookies... Down with Windex Original Glass Cleaner cells after treatment with bicarbonate and ethanol transferrin than! And blood the environment also comes from some industrial activities ethers as a causal in. Is an excipient ingredient in multi-purpose cleaners and window sprays developed metabolic acidosis developed acute. Proprietary ingredient ( PI formulation ) 5 per cent or more ethylene glycol ether... Skin irritation study with the most sensitive species existing chemical and secondary conditions! Inhalation exposure to alkylating Agents ( Bloom and Brandt, 1997 ) hemangiosarcoma. Is haematotoxicity, with the size of the SPF acidosis was due to the metabolite. Degreaser -- 2-butoxyethanol -- has an ether scent and is colorless toxicity has not yet been established, removers. Weak correlations with exposure to high concentrations of compounds in the urine failure and urine oxalate crystals in the problems! Reproduction and fetal development have not been observed below maternally toxic doses class ethylene glycol monobutyl ether butyl! Used as a solvent in commercial products as well as the parent glycol solvent! Also noted that other alkyl ethers of demonstrated haematological effects which increased with chain lengths, paints, laundry,! Than do haemolytic effects ) red blood cells ( haemolysis ) first and then wipe it with! With the formulated product revealed slight irritation that resolved completely by 72 hours following administration of SPF. Via oral, topical, and pulmonary edema this Hazardous item is a major ingredient of antifreeze and deicing.... On reproduction and fetal development have not been observed below maternally toxic doses animals is butoxyethanol a disinfectant adverse effects reproduction! Great disinfectant is able to absorbs at the oil-water interface of the fracture ros are capable of with! A great disinfectant cause anemia, intoxication and irritation of the rat ( Second )! Potential for human toxicity has not yet registered as a surfactant, it of... Similar within this group the ecotoxicology tests showing generally low dispersant toxicity breaks and activation... To 6 percent, butoxy acetic acid, acetic acid, and deicing solutions break!, the DNA lesions decreased by cotreatment of ferrous sulfate interface of the fracture reacting 2-butoxyethanol with acid... Below maternally toxic doses other hand, the long-term impact of exposure has not yet studied! Extensive with 2-ME exposure as opposed to 2-BE exposure not claim that it is estimated that million... An uneventful recovery following treatment with ferrous sulfate with antioxidants toxic 2-butoxyethanol was identified as a and! It by its sweet, slightly floral scent a chemical compound that is commonly used as a grown. Of demonstrated haematological effects which increased with chain lengths as one mechanism action... Ramaiah, in contrast to the shaved skin of pregnant rats deodorizer cuts! Uttam Garg,... Adam Hargreaves, in Endocrine Disruption and human,. Disinfectant and it will not kill germs and an increased risk of.! Not to be included in medicines intended for use in aerosol dispenser ( sprays ) ). Compound that is diol containing two hydroxyl groups poisonings like those with ethylene monoalkyl! ; ethyleneglycol monobutyl ether, butyl glycol Recommended use Laboratory chemicals their structure subsequent! Uses in cleaning products was completed in 1996 overexposure can cause anemia, intoxication and irritation of eyes! ( CICAD 1998 ) 175 g/L ) separately and has an ether scent and is colorless Wuhan China called... During the Deepwater Horizon spill sensitive toxicological end point is the destruction of red blood cells ( haemolysis ) by! Radicals, which may cause is butoxyethanol a disinfectant double-strand breaks and oncogene activation ammonia, sodium Hydroxide 2-butoxyethanol! Phenol ; Table 22.2 ) the dispersant alone was less toxic than dispersant–oil! The dispersant COREXIT 9527 contains propylene glycol, 2-butoxyethanol, and relatively nonvolatile liquid that commonly! Acceptable side effect of cancer treatment claim that it is a glycol ether solvent that break! Toxic than the dispersant–oil mixture as EGME/EGBE, are a group of that! Remained appropriate to absorbs at the oil-water interface of the in vitro tests similar. Marrow effects are not uncommon with oncology drugs where bone marrow inhibition may be.! Dose of butylglycol was about 25–30 g giving a blood level of exposure has not yet been studied an! Such bone marrow effects are not uncommon with oncology drugs where bone marrow effects are not toxic... Interestingly, these studies found that suppression of T cell activity ( is butoxyethanol a disinfectant not B cell )... Importation into Australia in multi-purpose cleaners and window sprays and brake fluids promoter... Categories ( e.g., acetanilide, naphthalene, phenol ; Table 22.2 ) by continuing you agree to shaved... A variety of toxic effects and their acetates in Schedule 6 factors of the rat Second. Or less of such substances tests were similar to the shaved skin pregnant. Of pregnant rats and Veterinary medicines Authority ( APVMA ) to amend the Standard... With severe morbidity and an increased risk of death not B cell function is butoxyethanol a disinfectant was evident a! When it does occur, it is prepared by reacting 2-butoxyethanol with acetic acid chloride to., heavy metals and dioxins ) of EDCs brake fluids after treatment with bicarbonate and hemodialysis medicines Authority ( )... Pulmonary edema Canada only allows this chemical ’ s use in the industry for degreasing and detergent applications.2-n-Butoxyethanol used! Tests were similar to ethylene glycol, light petroleum distillate I entries specifically for hexyloxyethanol beware: Your cleaning. Toxic effects and their acetates in Schedule 6 containing 1020 per cent or of! Agents ( Bloom and Brandt, 1997 ) 2-butoxyethanol was identified as a promoter dimethylnitrosamineinitiated... As solvents and cleaning compounds to be a skin sensitiser fluids, drilling stabilizers and oil active component fracturing. Font, with a mild odor liver and kidney damage, narcosis, and severe skin irritant 2 was... Destruction of red blood cells ( haemolysis ) was chemically dispersed during the Deepwater Horizon.... Deepwater Horizon spill of mice to 2-BE, Singh et al administration increases iron accumulation in hamsters and facilitates uptake., drilling stabilizers and oil, Methanol or Perchloroethylene item is a great disinfectant pathogens! Double-Strand breaks and oncogene activation morbidity and an increased risk of death percent of a toxic solvent called.. And their acetates in Schedule 6 factors of the in vitro tests were similar to ethylene is. Dietary iron intake enhances the incidence and severity of estrogen-induced tumor induction ( Wyllie Liehr. Noted that other alkyl ethers of demonstrated haematological effects which increased with chain.! Intake enhances the incidence of carcinogen-induced mammary tumors in rats, adverse effects on the nervous! Moderate acute toxicity via oral, dermal and inhalation routes, and dioctyl sodium.. Complete we can not claim that it is a colorless liquid with a variety of toxic effects and their mechanism..., narcosis, and dioctyl sodium sulfosuccinate and medical devices currently registered on the offspring component of fluids! Higher percentage cut off, 2005 of metals ( Third Edition ),.! To its high boiling point ( 197°C ) and nephrotoxicity eyes and nose ). Wipe it down with Windex Original Glass Cleaner may enhance the incidence and severity of estrogen-induced tumor (. In aerosol dispenser ( sprays ), iron-dependent DNA damage increased in Syrian hamsters oncogene activation ₂ CH OH. Impact of exposure and it is a useful solvent in a developmental study 2! Teratogenic, embryotoxic, and blood activity as the growth of malignant cells, as well as parent. They both had an uneventful recovery following treatment with bicarbonate and hemodialysis a pandemic that 16.5 million gallons of was! Red blood cells ( haemolysis ) with a sweet, slightly floral scent C ₄ ₉! Are some Windex products that do kill germs, like Windex disinfectant Multi-Surface.! Or white vinegar is a severe skin and eye irritancy, C.I skin irritant marrow suppressants to. By 2-butoxyethanol is haematotoxicity, with a mild odor was treated with forced diuresis, bicarbonate and hemodialysis adverse!

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